Experiment aborted because of a miscalculation of amine solution volume.
Log
2008-02-05
12:10 One dram vial charged with 1ml of methanol.
12:12 Amine in methanol solution was added to vial.
12:13 Vortexed for 15 seconds.
12:16 Added aldehyde to one dram vial.
12:17 Vortexed aldehyde for 5 minutes. Solution was obtained. It was not difficult to get a clear solution.
12:22 Added acid to vial. Even though the smallest pipette says 20ul it actually goes down to 10ul and up to 270ul. (how did you add 18.9 ul of formic acid? I thought our smallest micropipette had a min of 20 ul)
12:25 Vortexed for 15 seconds until solution was obtained.
12:26 Isocyanide was added to the vial, and vortexed for 5 mintues until solution was formed.
12:32 Picture was taken, but could not be uploaded onto the wiki due to a faulty connection with the camera.
2008-02-06
12:20 Picture was taken and no precipitate was formed.
Objective
To synthesize a Ugi product using Beta-methoxy-alpha-naphthaldehyde, Methylaminef, formic acid,and Tosylmethyl isocyanidefollowing the EXPLAN005 . The compound will contribute towards a library for Falcipain2 inhibitors.This compunds was ranked 22 in the DEXP014-V1B file from D-EXP014 .The purpose of this experiment is to synthesize an anti-malarial compound based on the inhibition of falcipain-2, as described in this summary post.
Procedure
As described in Explan005Density information found at the Ugi Chemicals page.
Results
all components
All results are recorded Master Table and Workflow Tables .
Discussion
Conclusion
Experiment aborted because of a miscalculation of amine solution volume.Log
2008-02-05
12:10 One dram vial charged with 1ml of methanol.12:12 Amine in methanol solution was added to vial.
12:13 Vortexed for 15 seconds.
12:16 Added aldehyde to one dram vial.
12:17 Vortexed aldehyde for 5 minutes. Solution was obtained. It was not difficult to get a clear solution.
12:22 Added acid to vial. Even though the smallest pipette says 20ul it actually goes down to 10ul and up to 270ul. (how did you add 18.9 ul of formic acid? I thought our smallest micropipette had a min of 20 ul)
12:25 Vortexed for 15 seconds until solution was obtained.
12:26 Isocyanide was added to the vial, and vortexed for 5 mintues until solution was formed.
12:32 Picture was taken, but could not be uploaded onto the wiki due to a faulty connection with the camera.
2008-02-06
12:20 Picture was taken and no precipitate was formed.Tags
Methylamine InChI=1/CH5N/c1-2/h2H2,1H3 InChIKey BAVYZALUXZFZLV-UHFFFAOYANTosylmethyl isocyanide InChI=1/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3 InChIKeyCFOAUYCPAUGDFF-UHFFFAOYAC
formic acid InChI=1/CH2O2/c2-1-3/h1H,(H,2,3) InChIKeyBDAGIHXWWSANSR-UHFFFAOYAT
Beta-methoxy-alpha-naphthaldehyde InChI=1/C12H10O2/c1-14-12-7-6-9-4-2-3-5-10(9)11(12)8-13/h2-8H,1H3 InChIKeyYIQGLTKAOHRZOL-UHFFFAOYAN
Ugi Product InChI=1/C2 3H24N2O5S/c1-16-8-11-18(12-9-16)31(28,29)14-24-23(27)22(25(2 )15-26)21-19-7-5-4-6-17(19)10-13-20(21)30-3/h4-13,15,22H,14H 2,1-3H3,(H,24,27) InChIKey RDBIZMTYKUDBFZ-UHFFFAOYAM